New PDF release: 7th Asian-Pacific Conference on Medical and Biological

By Peng Hu (auth.), Yi Peng, Xiaohong Weng (eds.)

This quantity provides the lawsuits of the 7th Asian-Pacific convention on scientific and organic Engineering (APCMBE 2008). Themed "Biomedical Engineering – selling Sustainable improvement of recent medication" the complaints deal with a large spectrum of themes from Bioengineering and Biomedicine, like Biomaterials, man made Organs, Tissue Engineering, Nanobiotechnology and Nanomedicine, Biomedical Imaging, Bio MEMS, Biosignal Processing, electronic medication, BME schooling. It is helping scientific and organic engineering pros to have interaction and alternate their principles and experiences.

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Langer, R. (1994). Biodegradable long-circulating polymeric nanospheres. Science, 263, 1600-1603. Kabanov, A. , Nazarova, I. , Astafieva, I. , Batrakova, E. , Alakhov, V. , Yaroslavov, A. , et al. (1995). Micelle formation and solubilization of fluorescent probes in poly (oxyethylene-boxypropylene-b-oxyethylene) solutions. Macromolecules, 28, 23032314. Lee, S. , Kwon, I. , et al. (1999). Synthesis and micellar characterization of amphiphilic diblock copolymers based on poly (2-ethyl-2-oxazoline) and aliphatic polyesters 1.

Keywords — Polyethylenimiene, poly (ethylene glycol, cationic polymer, cytotoxicity, gene delivery. I. INTRODUCTION Gene therapy has been regarded as the promising and ultimate cure for many life-threatening diseases, acquired and inherited, such as AIDS, cancer, genetic disordered etc [1] and [2]. To achieve successful gene therapy, development of proper gene delivery systems should be one of the most significant factors [3] and [4]. Among non-viral carriers, polyethylenimine (PEI) has been one of the most widely studied synthetic cationic gene vectors due to its superior transfection efficiency [3] and [4].

The structure of pullulan predominantly consists of maltotriose units linked via a-1,6 glycosidic bonds and mainly used as a food additive now. Pullulan has several advantages as a macromolecular drug carrier. It is highly water-soluble and non-toxic, has multiple hydroxyl groups that can readily be chemically modified, lacks immunogenicity, and is useful as a plasma expander. Several researchers have modified the pullulan with palmitoyl or cholesteryl moieties [25-28]. In the past investigation, pullulan was modified with cholesterol moiety by the hexamethylene diisocynate as a arm and in this reaction 1,4-diazabicyclo(2,2,2)octane was used as a catalyst.

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