Download e-book for iPad: Abl Family Kinases in Development and Disease (Molecular by Anthony Koleske

By Anthony Koleske

Abl family members Kinases in improvement and affliction offers an summary of the features of Abl family members kinases in improvement and sickness. This new name discusses the biochemical, genetic, and mobilephone organic facts that elucidate the mobile roles for those kinases in those methods.

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Extra info for Abl Family Kinases in Development and Disease (Molecular Biology Intelligence Unit)

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67. Slack-Davis JK, Parsons J T . Emerging views of integrin signaling: implications for prostate cancer. J Cell Biochem 2004; 9 1 ( l ) : 4 l - 4 6 . 68. Sini P, Cannas A, Koleske AJ et al. Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation. N a t Cell Biol 2004; 6(3):268-274. 69. Wisniewski D , Strife A, Wojciechowicz D et al. A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations.

As discussed above, improper regulation of integrin signaling cascades by Bcr-Abl likely contributes to the abnormal expansion and trafficking of CML progenitors. The inability to properly respond to adhesive cues may also explain some of the defects observed in mice lacking Abl or Arg. Y. Moresco and Anthony J. ^^' More work is required to determine whether defects in Abl family kinase signaling contribute to these or other human disorders. Acknowledgments We would like to thank Tony Koleske, Bill Bradley, Scott Boyle, and Stefanie Lapetina for helpftil comments on this manuscript.

69. Wisniewski D , Strife A, Wojciechowicz D et al. A 62-kilodalton tyrosine phosphoprotein constitutively present in primary chronic phase chronic myelogenous leukemia enriched lineage negative blast populations. Leukemia 1994; 8(4):688-693. 70. Carpino N , Wisniewski D , Strife A et al. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 1997; 88(2): 197-204. 7 1 . Yamanashi Y, Baltimore D . Identification of the Abl- and rasGAP-associated 62 IcDa protein as a docking protein, Dok.

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