New PDF release: An Antigen Depository of the Immune System: Follicular

By A. K. Szakal, Z. F. Kapasi, S. T. Haley (auth.), Marie H. Kosco-Vilbois (eds.)

Follicular dendritic cells (FOe) are detailed between cells of the immune approach. whereas their morphological features re­ sulted of their inclusion as a 'dendritic telephone type', tt1ey vary relatively considerably from the opposite contributors of the dendritic mobilephone relations. not like T-cell-associated dendritic cells or the Langerhans cells present in the outside, FOe stay in hugely geared up B cellphone follicles inside of secondary lymphoid tissues. This website of resi­ dence supplied a nomenclature committee in 1982 with the second one descriptive issue for the derivation in their identify. The cardinal characteristic of FOe is to seize and preserve antigen at the floor in their dendritic approaches for prolonged quantities of time and it really is this selection that offers the conceptual compo­ nent for the identify of this publication. in keeping with an antigenic problem, fundamental B cellphone follicles endure dynamic occasions, giving upward push to germinal facilities that are linked to activation, growth, and differentiation tactics of B cells. The interactions of B cells with Foe and T cells within the germinal facilities are crucial for producing the entire repertoire of antibody isotypes acquired in the course of an antibody reaction. moreover, stimuli both initiated or major­ tained throughout the germinal heart reponse results in construction of excessive affinity antibodies in the course of the tactics of somatic muta­ tion and clonal choice. during this context, FOe act as a pivotal resource of antigen. They gather overseas proteins (e. g.

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Third, interaction via MHC class II molecules can effect other signals. The MHC molecules also help transmit signals inside the B cells; for example, binding of anti-MHC II antibodies to B cells can block their multiplication and activation by increasing the intracellular cyclic adenosine monophosphate (cAMP) concentration (NEWELL et al. 1993). Follicular Dendritic Cells: Origin and Function 25 In conclusion, FOC by themselves do not appear to stimulate virgin IgM+ IgO+ B cells, but rather sustain the activation of antigen-specific B cells preactivated in the T-dependent area.

Szakal AK, Tew JG (1988) In vivo obtained antigen presented by germinal center B cells to T cells in vivo.

1991) did not detect this cytokine in germinal centers by in situ hybridization, data confirmed by histochemistry by HOEFAKKER et al. (1993). CD4+ CD5J+ cells do not divide immediately after isolation, and even the presence of FDC cells does not induce their proliferation (Fig . 4 ; BOUZAHZAH et al. 11000 / L .. I I T 8800 / I / 8 fr 4400 / 2200 o /7 - . I I r- I 2 IIJ II 3 4 Fig. 3. Proliferation capacity of tonsillar B cells cultured in contact with C04' T cells. Tritiated thymidine incorporation was measured after 2 days of culture in the presence of phytohemagglutinin (PHA) .

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