G. Aumüller, P. M. Holterhus, W. Eicheler (auth.), Martin's Apoptosis in Hormone-Dependent Cancers PDF

By G. Aumüller, P. M. Holterhus, W. Eicheler (auth.), Martin Tenniswood, Horst Michna (eds.)

It is now extensively permitted that cells be ready to start up a application of gene-directed loss of life, a procedure referred to as "apoptosis" that could even be used as an cutting edge process for healing intervention in melanoma remedy. specialists during this sector document at the law and keep an eye on of apoptosis in hormone based (neoplastic) tissue and the chance to use lively mobilephone loss of life for healing application.

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References Aumtiller G, Groschel-Stewart U, Altmannsberger M, Mannherz HG, Steinhoff M (1991) Basal cells of H-Dunning tumor are myoepithelial cells. Biochemistry 95:341-349 Buttyan R, Zakeri Z, Lockshin R, Wolgemuth D (1988) Cascade induction of c-fos, c-myc, and heat shock 70 K transcripts. Mol Endocrinol 2:650-657 Carter BS, Carter HB, Isaacs JT (1990) Epidemiologic evidence regarding predisposing factors to prostate cancer. Prostate 16: 187-197 Colombe! M, Olsson CA, Ng PY, Buttyan R (1992) Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.

Detection of Apoptosis in LNCaP Cell Cultures . . . . . . . . Miscellaneous . . . . . . . . . . . . . . . . . . . . . Results and Discussion . . . . . . . . . . . . . . . . . . Development of Human Prostate Tumor Xenograft Models . . . Properties of the Established Human Prostate Xenografts ....... Cell Death in the PC-82 and PC-EW Tumor Models . . . . . . Expression of Some Cell Death-Related Gene Products in Prostate Xenografts .

Tissue-Type Transglutaminase. Throughout prostatic growth and differentiation only very few cells showed a positive TGase immunoreaction. This was particularly true for metaplastic foci, which were devoid of any TGase immunoreactivity. Only in a few BPH and cancer specimens was the number of TGase-immunoreactive cells increased. Terminal Transferase Reaction. The terminal transferase reaction was only performed in a few specimens, one fetal and two postnatal. 1% in the immature glands. In fetal specimens, obviously condensed nuclei indicating apoptosis did not react, perhaps due to partial extraction or excessive denaturation of the tissue.

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