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By L. D. Bergelson (auth.), Gheorghe Benga, Joseph M. Tager (eds.)

Membrane study holds a principal place in mobilephone and molecular biology. in recent times it has turn into transparent that the examine of membranes on the molecular point is of significant significance not just to decipher all mobile approaches but additionally to appreciate the changes resulting in irregular cells (including melanoma cells) and/or to appreciate the motion of varied medicines. This publication covers the multidisciplinary technique of analysis during this region and the everlasting want for info relating to fresh advances. it's going to serve either staff learning simple points of membrane constitution and serve as in addition to medically orientated scientists. the choice of themes illustrating interconnections among uncomplicated and utilized membrane biology will cross-fertilize study in either groups.

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The presence of contractile elements of the cytoskeleton is certainly directly participating in creating and maintaining the localization of membrane proteins. ATPdriven, directed motion of protein species attached to the cytoskeleton to specialized zones of the cell surface has often been proposed to account for localizing movement (Heath 1983). The influence exerted by the cytoskeleton on redistribution of immunoglobulins on the B-Iymphocyte surface upon binding with antigens has received much attention.

Effects of Fluidity on Protein Dynamics 17 Table 2. Some factors affecting membrane fluidity Factor Physical Temperature Pressure Membrane potential Chemical Lipid species and fatty acid unsaturation Cholesterol Lipid peroxidation Ubiquinones Lipid-soluble vitamins Integral proteins Peripheral proteins Cytoskeleton pH and ions Detergents Organic solvents, anesthetics Water-soluble polymers Indirect Hormones Adaptation to stress, etc. Cell cycle, growth, differentiation Phospholipid methylation Antibody binding Selected references Shinitzky and Inbar 1976, Lenaz et al.

CRC Press, Boca Raton, pp 159-188 Berg HC (1983) Random walks in biology. Princeton Univ Press, Princeton NJ Berg HC, Purcell EM (1977) Physics of chemoreception. Biophys J 20: 193-219 Berg OG, Hippe! PH von (1985) Diffusion-controlled macromolecular interactions. Annu Rev Biophys Biophys Chern 14:131-160 Berliner U (ed) (1979) Spin labeling. II. Theory and applications. Academic Press, London New York Bertoli E, Finean JB, Griffiths DE (1976) The role of lipid in regulation of mitochondrial adenosine triphosphatase.

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