S. Nassir Ghaemi, Rif S. El-Mallakh's Bipolar Depression: A Comprehensive Guide PDF

By S. Nassir Ghaemi, Rif S. El-Mallakh

Even if melancholy is the commonest presentation of bipolar ailment, right prognosis in general calls for a heritage of mania and therefore offers a powerful problem. This e-book offers clinicians with the required counsel to tell apart this disorder and pursue a suitable healing direction. It brings jointly a workforce of scientific investigators who supply state of the art examine at the subject and deal with the main serious issues relating to its remedy. Bipolar melancholy first introduces a hierarchical version for analysis to permit the clinician to differentiate among bipolar and unipolar melancholy, addressing difficulties of misdiagnosis and overdiagnosis in addition to differentiating attention-deficit/hyperactivity affliction (ADHD) and bipolar affliction. Early chapters assessment the neurobiology and genetics of this hugely heritable , proposing stories of neurotransmitter functionality and mind imaging experiences and documenting the susceptibility of particular chromosomes as loci for bipolar affliction. different chapters tackle the actual problems with bipolar melancholy in childrens, for whom a analysis is mainly tricky, and suicide, targeting the necessity for evaluation in the course of either acute and upkeep therapy with interventions acceptable to a patient's signs and historical past. Bipolar melancholy deals opinions of particular remedy ways: -Lithium and antiepileptic medicines: that includes a assessment of the latest study at the use of lithium, during which larger doses are proven to be powerful, plus insurance of lamotrigine, valproic acid, carbamazepine, oxcarbazepine, and topiramate. -Antidepressants: supplying new views on a posh box, together with a dialogue of the randomized medical trial literature and observational experiences on their use, and mentioning cautions relating to negative effects. -Antipsychotics: comparing the variation among first- and second-generation medicinal drugs and discussing their function in controlling acute depressions. -Novel techniques to therapy: together with using bizarre neuroleptics, electroconvulsive treatment, transcranial magnetic stimulation, vagus nerve stimulation, ketogenic vitamin, omega-3 fatty acids, myo-inositol, and dopamine agonists. -Psychological interventions: targeting the inclusion of cognitive-behavioral remedy or interpersonal social rhythm treatment for nonmelancholic depressions in sufferers who had formerly obtained psychoeducation. regardless of the earlier decade's advances in perform and study, there continues to be a lot room for development in realizing and treating bipolar melancholy. This ebook blazes a path towards that objective, commencing new doorways in spotting modifications among bipolar and unipolar varieties of melancholy whereas providing either researchers and clinicians key insights into this troubling affliction.

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Bipolar Disord 3:53–57, 2001 Dell’Osso L, Pini S, Cassano GB, et al: Insight into illness in patients with mania, mixed mania, bipolar depression and major depression with psychotic features. Bipolar Disord 4:315–322, 2002 Dilsaver SC, Swann AC: Mixed mania: apparent induction by a tricyclic antidepressant in five consecutively treated patients with bipolar depression. Biol Psychiatry 37:60–62, 1995 Dilsaver S, Chen Y, Swann A, et al: Suicidality in patients with pure and depressive mania. Am J Psychiatry 151:1312–1315, 1994 Dube S, Andersen SW, Sofia P, et al: Meta-analysis of olanzapine-fluoxetine in treatment-resistant depression (abstract).

Br J Psychiatry 172:23–28, 1998 Khan A, Warne HA, Brown WA: Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: an analysis of the Food and Drug Administration database. Arch Gen Psychiatry 57:311–317, 2000 Koukopoulos A, Koukopoulos A: Agitated depression as a mixed state and the problem of melancholia. Psychiatr Clin North Am 22:547–564, 1999 Kraepelin E: Manic-Depressive Insanity and Paranoia. Translated by Barclay RM and edited by Robertson GM.

1997b) and are responsible for glutamate clearance. If glial function is diminished, a build up of glutamate could result in overexcitation of neurons (Schurr 2002; Schurr et al. 1997a) with consequent excitotoxicity (Lipton 2004). Several studies have found alterations in glial density in bipolar brain tissue when compared with normal controls: Ongur et al. (1998) found a substantial decrease in glial density in patients with bipolar disorder in the subgenual part of the anterior cingulate cortex (ACC) and Neurobiology of Bipolar Depression 47 the subgenual part of the prefrontal cortex; Chana et al.

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