By J. Walden, H. Grunze
Complement factor: Neuropsychobiology 2000, Vol. forty two, Suppl. 1
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Extra info for Bipolar Illnesses: New Ways of Treatment (Stanley Symposium, Munich, October 1999 (Neuropsychobiology))
Therefore, the observed motor impairments obviously reflected a state marker of the disease and not a trait. g. cortisol levels in blood or electroencephalographic activities . The biological findings and especially the assessment of the handwriting abilities provide some implications for an understanding of the pathogenetic mechanisms generating affective disorders, since they trace the rhythmic changes of the psychopathological state in such patients. The stabilization of the parameters for automatization under the treatment with valproate supports this view.
Only drowsiness was described as noteworthy during combination treatment. The patient was not in a depressive mood before the IFN-· treatments. In contrast to the monotherapeutic regime with IFN-· in 1996, the patient was under continuous antidepressive treatment during both combination therapies. Serotonergic-acting antidepressants have recently been shown to be effective in preventing psychiatric side effects with high-dose interferon treatment for malignant melanoma given before starting the IFN-· treatment .
Prospective psychiatric ratings like the BPRS (Brief Psychiatric Rating Scale) or the Montgomery-Asberg Depression Scale, as well as self-rating instruments for anxiety and depressive symptoms (STAIX1, SDS) showed no relevant negative changes (fig. 1). However, the PCR for hepatitis C virus detection was still positive after 6 months, and the patient was considered as not responding to this treatment. Schäfer/Schmidt/Amann/Schlösser/ Loeschke/Grunze Discussion Comparing combination treatment with IFN-· monotherapy, the patient experienced aggressive feelings, anxiety, lack of drive, irritability, depressive mood, sleeping disturbance, loss of interests, ambivalence, disturbance of concentration, rumination, suicidal thoughts, mood instability and inner restlessness only during monotherapy.